A20/Nrdp1 interaction alters the inflammatory signaling profile by mediating K48- and K63-linked polyubiquitination of effectors MyD88 and TBK1

A20 is a potent anti-inflammatory protein that mediates both inflammation and ubiquitination in mammals, but the related mechanisms are not clear. In this study, we performed mass spectrometry (MS) screening, gene ontology (GO) analysis, and coimmunoprecipitation (co-IP) in a lipopolysaccharide (LPS...

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Vydáno v:J Biol Chem
Hlavní autoři: Meng, Zhaoyou, Xu, Rui, Xie, Lexing, Wu, Yutong, He, Qian, Gao, Pan, He, Xiaohui, Chen, Qiong, Xie, Qi, Zhang, Jiqiang, Yang, Qingwu
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2021
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8233150/
https://ncbi.nlm.nih.gov/pubmed/34023381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100811
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