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ErbB2 Trafficking and Degradation Associated with K48 and K63 Polyubiquitination
The overexpressed ErbB2/HER2 receptor is a clinically validated cancer target whose surface localization and internalization mechanisms remain poorly understood. Downregulation of the overexpressed 185 kDa ErbB2 receptor is rapidly (2–6 h) induced by the HSP90 chaperone inhibitor, geldanamycin (GA),...
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| Hoofdauteurs: | , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2010
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2862137/ https://ncbi.nlm.nih.gov/pubmed/20406983 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-3768 |
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