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ErbB2 Trafficking and Degradation Associated with K48 and K63 Polyubiquitination

The overexpressed ErbB2/HER2 receptor is a clinically validated cancer target whose surface localization and internalization mechanisms remain poorly understood. Downregulation of the overexpressed 185 kDa ErbB2 receptor is rapidly (2–6 h) induced by the HSP90 chaperone inhibitor, geldanamycin (GA),...

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Detalhes bibliográficos
Main Authors: Marx, Corina, Held, Jason M., Gibson, Bradford W., Benz, Christopher C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2862137/
https://ncbi.nlm.nih.gov/pubmed/20406983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-3768
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