Engineering of CD19 Antibodies: A CD19-TRAIL Fusion Construct Specifically Induces Apoptosis in B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) Cells In Vivo

B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is the most frequent malignancy in children and also occurs in adulthood. Despite high cure rates, BCP-ALL chemotherapy can be highly toxic. This type of toxicity can most likely be reduced by antibody-based immunotherapy targeting the CD19 ant...

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Detalhes bibliográficos
Publicado no:J Clin Med
Main Authors: Winterberg, Dorothee, Lenk, Lennart, Oßwald, Maren, Vogiatzi, Fotini, Gehlert, Carina Lynn, Frielitz, Fabian-Simon, Klausz, Katja, Rösner, Thies, Valerius, Thomas, Trauzold, Anna, Peipp, Matthias, Kellner, Christian, Schewe, Denis Martin
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8232684/
https://ncbi.nlm.nih.gov/pubmed/34203833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/jcm10122634
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