Enhancing CDC and ADCC of CD19 Antibodies by Combining Fc Protein-Engineering with Fc Glyco-Engineering

Background: Native cluster of differentiation (CD) 19 targeting antibodies are poorly effective in triggering antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC), which are crucial effector functions of therapeutic antibodies in cancer immunotherapy. Both...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Antibodies (Basel)
Huvudupphovsmän: Roßkopf, Sophia, Eichholz, Klara Marie, Winterberg, Dorothee, Diemer, Katarina Julia, Lutz, Sebastian, Münnich, Ira Alexandra, Klausz, Katja, Rösner, Thies, Valerius, Thomas, Schewe, Denis Martin, Humpe, Andreas, Gramatzki, Martin, Peipp, Matthias, Kellner, Christian
Materialtyp: Artigo
Språk:Inglês
Publicerad: MDPI 2020
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7709100/
https://ncbi.nlm.nih.gov/pubmed/33212776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antib9040063
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk