An Fc Double-Engineered CD20 Antibody with Enhanced Ability to Trigger Complement-Dependent Cytotoxicity and Antibody-Dependent Cell-Mediated Cytotoxicity

BACKGROUND: Engineering of the antibody's fragment crystallizable (Fc) by modifying the amino acid sequence (Fc protein engineering) or the glycosylation pattern (Fc glyco-engineering) allows enhancing effector functions of tumor targeting antibodies. Here, we investigated whether complement-de...

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Detalhes bibliográficos
Publicado no:Transfus Med Hemother
Main Authors: Wirt, Tim, Rosskopf, Sophia, Rösner, Thies, Eichholz, Klara Marie, Kahrs, Anne, Lutz, Sebastian, Kretschmer, Anna, Valerius, Thomas, Klausz, Katja, Otte, Anna, Gramatzki, Martin, Peipp, Matthias, Kellner, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: S. Karger GmbH 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5649312/
https://ncbi.nlm.nih.gov/pubmed/29070974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000479978
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