Multi-Target Directed Ligands (MTDLs) Binding the σ(1) Receptor as Promising Therapeutics: State of the Art and Perspectives

The sigma-1 (σ(1)) receptor is a ‘pluripotent chaperone’ protein mainly expressed at the mitochondria–endoplasmic reticulum membrane interfaces where it interacts with several client proteins. This feature renders the σ(1) receptor an ideal target for the development of multifunctional ligands, whos...

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Vydáno v:Int J Mol Sci
Hlavní autoři: Abatematteo, Francesca Serena, Niso, Mauro, Contino, Marialessandra, Leopoldo, Marcello, Abate, Carmen
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2021
Témata:
Review
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8232171/
https://ncbi.nlm.nih.gov/pubmed/34198620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22126359
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