Prevalence and Characterization of Biallelic and Monoallelic NTHL1 and MSH3 Variant Carriers From a Pan-Cancer Patient Population

NTHL1 and MSH3 have been implicated as autosomal recessive cancer predisposition genes. Although individuals with biallelic NTHL1 and MSH3 pathogenic variants (PVs) have increased cancer and polyposis risk, risks for monoallelic carriers are uncertain. We sought to assess the prevalence and characte...

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Detalhes bibliográficos
Publicado no:JCO Precis Oncol
Main Authors: Salo-Mullen, Erin E., Maio, Anna, Mukherjee, Semanti, Bandlamudi, Chaitanya, Shia, Jinru, Kemel, Yelena, Cadoo, Karen A., Liu, Ying, Carlo, Maria, Ranganathan, Megha, Kane, Sarah, Srinivasan, Preethi, Chavan, Shweta S., Donoghue, Mark T. A., Bourque, Caitlin, Sheehan, Margaret, Tejada, Prince Rainier, Patel, Zalak, Arnold, Angela G., Kennedy, Jennifer A., Amoroso, Kimberly, Breen, Kelsey, Catchings, Amanda, Sacca, Rosalba, Marcell, Vanessa, Markowitz, Arnold J., Latham, Alicia, Walsh, Michael, Misyura, Maksym, Ceyhan-Birsoy, Ozge, Solit, David B., Berger, Michael F., Robson, Mark E., Taylor, Barry S., Offit, Kenneth, Mandelker, Diana, Stadler, Zsofia K.
Formato: Artigo
Idioma:Inglês
Publicado em: Wolters Kluwer Health 2021
Assuntos:
ORIGINAL REPORTS
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8232072/
https://ncbi.nlm.nih.gov/pubmed/34250384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.20.00443
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