Risk of extracolonic cancers for people with biallelic and monoallelic mutations in MUTYH

Germline mutations in the DNA base excision repair gene MUTYH are known to increase a carrier’s risk of colorectal cancer. However, the risks of other (extracolonic) cancers for MUTYH mutation carriers are not well defined. We identified 266 probands (91% Caucasians) with a MUTYH mutation (41 bialle...

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I publikationen:Int J Cancer
Huvudupphovsmän: Win, Aung Ko, Reece, Jeanette C., Dowty, James G., Buchanan, Daniel D., Clendenning, Mark, Rosty, Christophe, Southey, Melissa C., Young, Joanne P., Cleary, Sean P., Kim, Hyeja, Cotterchio, Michelle, Macrae, Finlay A., Tucker, Katherine M., Baron, John A., Burnett, Terrilea, Le Marchand, Loïc, Casey, Graham, Haile, Robert W., Newcomb, Polly A., Thibodeau, Stephen N., Hopper, John L., Gallinger, Steven, Winship, Ingrid M., Lindor, Noralane M., Jenkins, Mark A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5094810/
https://ncbi.nlm.nih.gov/pubmed/27194394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.30197
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