Risk of extracolonic cancers for people with biallelic and monoallelic mutations in MUTYH

Germline mutations in the DNA base excision repair gene MUTYH are known to increase a carrier’s risk of colorectal cancer. However, the risks of other (extracolonic) cancers for MUTYH mutation carriers are not well defined. We identified 266 probands (91% Caucasians) with a MUTYH mutation (41 bialle...

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Detalhes bibliográficos
Publicado no:Int J Cancer
Main Authors: Win, Aung Ko, Reece, Jeanette C., Dowty, James G., Buchanan, Daniel D., Clendenning, Mark, Rosty, Christophe, Southey, Melissa C., Young, Joanne P., Cleary, Sean P., Kim, Hyeja, Cotterchio, Michelle, Macrae, Finlay A., Tucker, Katherine M., Baron, John A., Burnett, Terrilea, Le Marchand, Loïc, Casey, Graham, Haile, Robert W., Newcomb, Polly A., Thibodeau, Stephen N., Hopper, John L., Gallinger, Steven, Winship, Ingrid M., Lindor, Noralane M., Jenkins, Mark A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5094810/
https://ncbi.nlm.nih.gov/pubmed/27194394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.30197
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