Risk of extracolonic cancers for people with biallelic and monoallelic mutations in MUTYH

Germline mutations in the DNA base excision repair gene MUTYH are known to increase a carrier’s risk of colorectal cancer. However, the risks of other (extracolonic) cancers for MUTYH mutation carriers are not well defined. We identified 266 probands (91% Caucasians) with a MUTYH mutation (41 bialle...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Int J Cancer
Prif Awduron: Win, Aung Ko, Reece, Jeanette C., Dowty, James G., Buchanan, Daniel D., Clendenning, Mark, Rosty, Christophe, Southey, Melissa C., Young, Joanne P., Cleary, Sean P., Kim, Hyeja, Cotterchio, Michelle, Macrae, Finlay A., Tucker, Katherine M., Baron, John A., Burnett, Terrilea, Le Marchand, Loïc, Casey, Graham, Haile, Robert W., Newcomb, Polly A., Thibodeau, Stephen N., Hopper, John L., Gallinger, Steven, Winship, Ingrid M., Lindor, Noralane M., Jenkins, Mark A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5094810/
https://ncbi.nlm.nih.gov/pubmed/27194394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.30197
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