Risk of Colorectal Cancer for Carriers of Mutations in MUTYH, with and without a Family History of Cancer

We studied 2332 individuals with monoallelic mutations in MUTYH among 9504 relatives of 264 colorectal cancer (CRC) cases with a MUTYH mutation. We estimated CRC risks, through 70 y of age, of 7.2% for male carriers of monoallelic mutations (95% confidence interval [CI], 4.6%–11.3%) and 5.6% for fem...

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Main Authors: Win, Aung Ko, Dowty, James G., Cleary, Sean P., Kim, Hyeja, Buchanan, Daniel D., Young, Joanne P., Clendenning, Mark, Rosty, Christophe, MacInnis, Robert J., Giles, Graham G., Boussioutas, Alex, Macrae, Finlay A., Parry, Susan, Goldblatt, Jack, Baron, John A., Burnett, Terrilea, Marchand, Loïc Le, Newcomb, Polly A., Haile, Robert W., Hopper, John L., Cotterchio, Michelle, Gallinger, Steven, Lindor, Noralane M., Tucker, Katherine M., Winship, Ingrid M., Jenkins, Mark A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3992182/
https://ncbi.nlm.nih.gov/pubmed/24444654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2014.01.022
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