Prevalence and Characterization of Biallelic and Monoallelic NTHL1 and MSH3 Variant Carriers From a Pan-Cancer Patient Population

NTHL1 and MSH3 have been implicated as autosomal recessive cancer predisposition genes. Although individuals with biallelic NTHL1 and MSH3 pathogenic variants (PVs) have increased cancer and polyposis risk, risks for monoallelic carriers are uncertain. We sought to assess the prevalence and characte...

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محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:JCO Precis Oncol
المؤلفون الرئيسيون: Salo-Mullen, Erin E., Maio, Anna, Mukherjee, Semanti, Bandlamudi, Chaitanya, Shia, Jinru, Kemel, Yelena, Cadoo, Karen A., Liu, Ying, Carlo, Maria, Ranganathan, Megha, Kane, Sarah, Srinivasan, Preethi, Chavan, Shweta S., Donoghue, Mark T. A., Bourque, Caitlin, Sheehan, Margaret, Tejada, Prince Rainier, Patel, Zalak, Arnold, Angela G., Kennedy, Jennifer A., Amoroso, Kimberly, Breen, Kelsey, Catchings, Amanda, Sacca, Rosalba, Marcell, Vanessa, Markowitz, Arnold J., Latham, Alicia, Walsh, Michael, Misyura, Maksym, Ceyhan-Birsoy, Ozge, Solit, David B., Berger, Michael F., Robson, Mark E., Taylor, Barry S., Offit, Kenneth, Mandelker, Diana, Stadler, Zsofia K.
التنسيق: Artigo
اللغة:Inglês
منشور في: Wolters Kluwer Health 2021
الموضوعات:
ORIGINAL REPORTS
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC8232072/
https://ncbi.nlm.nih.gov/pubmed/34250384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.20.00443
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