Local Colonic Administration of a Serine Protease Inhibitor Improves Post-Inflammatory Visceral Hypersensitivity in Rats

Dysregulation of the protease–antiprotease balance in the gastrointestinal tract has been suggested as a mechanism underlying visceral hypersensitivity in conditions such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). We aimed to study the potential therapeutic role of an in...

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Udgivet i:Pharmaceutics
Main Authors: Hanning, Nikita, De bruyn, Michelle, Ceuleers, Hannah, Boogaerts, Tim, Berg, Maya, Smet, Annemieke, De Schepper, Heiko U., Joossens, Jurgen, van Nuijs, Alexander L. N., De Man, Joris G., Augustyns, Koen, De Meester, Ingrid, De Winter, Benedicte Y.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8229129/
https://ncbi.nlm.nih.gov/pubmed/34072320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics13060811
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