The Effect of a Novel Serine Protease Inhibitor on Inflammation and Intestinal Permeability in a Murine Colitis Transfer Model

Background: A protease/antiprotease disbalance is observed in inflammatory bowel diseases (IBD). We therefore studied the effect of the novel serine protease inhibitor UAMC-00050 on intestinal inflammation and permeability in a chronic colitis T cell transfer mouse model to get further insight into...

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Pubblicato in:Front Pharmacol
Autori principali: Van Spaendonk, Hanne, Ceuleers, Hannah, Smet, Annemieke, Berg, Maya, Joossens, Jurgen, Van der Veken, Pieter, Francque, Sven M., Lambeir, Anne-Marie, De Man, Joris G., De Meester, Ingrid, Augustyns, Koen, De Winter, Benedicte Y.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2021
Soggetti:
Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8264366/
https://ncbi.nlm.nih.gov/pubmed/34248633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.682065
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