Newly developed serine protease inhibitors decrease visceral hypersensitivity in a post‐inflammatory rat model for irritable bowel syndrome

BACKGROUND AND PURPOSE: Serine proteases have been re suggested as important mediators of visceral pain. We investigated their effect by using newly developed serine protease inhibitors with a well‐characterized inhibitory profile in a rat model of post‐inflammatory irritable bowel syndrome (IBS). E...

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Gepubliceerd in:Br J Pharmacol
Hoofdauteurs: Ceuleers, Hannah, Hanning, Nikita, Heirbaut, Jelena, Van Remoortel, Samuel, Joossens, Jurgen, Van Der Veken, Pieter, Francque, Sven M, De bruyn, Michelle, Lambeir, Anne‐Marie, De Man, Joris G, Timmermans, Jean‐Pierre, Augustyns, Koen, De Meester, Ingrid, De Winter, Benedicte Y
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2018
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Research Papers
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6086981/
https://ncbi.nlm.nih.gov/pubmed/29911328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14396
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