P2X(3) Receptors Mediate Visceral Hypersensitivity during Acute Chemically-Induced Colitis and in the Post-Inflammatory Phase via Different Mechanisms of Sensitization

OBJECTIVES: Experiments using P2X(3) knock-out mice or more general P2X receptor antagonists suggest that P2X(3) receptors contribute to visceral hypersensitivity. We aimed to investigate the effect of the selective P2X(3) antagonist A-317491 on visceral sensitivity under physiological conditions, d...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Deiteren, Annemie, van der Linden, Laura, de Wit, Anouk, Ceuleers, Hannah, Buckinx, Roeland, Timmermans, Jean-Pierre, Moreels, Tom G., Pelckmans, Paul A., De Man, Joris G., De Winter, Benedicte Y.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4401691/
https://ncbi.nlm.nih.gov/pubmed/25885345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0123810
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