Endothelial Insulin Receptors Promote VEGF-A Signaling via ERK1/2 and Sprouting Angiogenesis

Endothelial insulin receptors (Insr) promote sprouting angiogenesis, although the underpinning cellular and molecular mechanisms are unknown. Comparing mice with whole-body insulin receptor haploinsufficiency (Insr(+/-)) against littermate controls, we found impaired limb perfusion and muscle capill...

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Vydáno v:Endocrinology
Hlavní autoři: Walker, Andrew M N, Warmke, Nele, Mercer, Ben, Watt, Nicole T, Mughal, Romana, Smith, Jessica, Galloway, Stacey, Haywood, Natalie J, Soomro, Taha, Griffin, Kathryn J, Wheatcroft, Stephen B, Yuldasheva, Nadira Y, Beech, David J, Carmeliet, Peter, Kearney, Mark T, Cubbon, Richard M
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2021
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Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8223729/
https://ncbi.nlm.nih.gov/pubmed/34037749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/endocr/bqab104
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