Endothelial Insulin Receptor Restoration Rescues Vascular Function in Male Insulin Receptor Haploinsufficient Mice

Reduced systemic insulin signaling promotes endothelial dysfunction and diminished endogenous vascular repair. We investigated whether restoration of endothelial insulin receptor expression could rescue this phenotype. Insulin receptor knockout (IRKO) mice were crossed with mice expressing a human i...

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Detalhes bibliográficos
Publicado no:Endocrinology
Main Authors: Sengupta, Anshuman, Patel, Peysh A, Yuldasheva, Nadira Y, Mughal, Romana S, Galloway, Stacey, Viswambharan, Hema, Walker, Andrew M N, Aziz, Amir, Smith, Jessica, Ali, Noman, Mercer, Ben N, Imrie, Helen, Sukumar, Piruthivi, Wheatcroft, Stephen B, Kearney, Mark T, Cubbon, Richard M
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6047419/
https://ncbi.nlm.nih.gov/pubmed/29796592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2018-00215
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