Novel Role of the IGF-1 Receptor in Endothelial Function and Repair: Studies in Endothelium-Targeted IGF-1 Receptor Transgenic Mice

We recently demonstrated that reducing IGF-1 receptor (IGF-1R) numbers in the endothelium enhances nitric oxide (NO) bioavailability and endothelial cell insulin sensitivity. In the present report, we aimed to examine the effect of increasing IGF-1R on endothelial cell function and repair. To examin...

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Dettagli Bibliografici
Autori principali: Imrie, Helen, Viswambharan, Hema, Sukumar, Piruthivi, Abbas, Afroze, Cubbon, Richard M., Yuldasheva, Nadira, Gage, Matthew, Smith, Jessica, Galloway, Stacey, Skromna, Anna, Rashid, Sheik Taqweer, Futers, T. Simon, Xuan, Shouhong, Gatenby, V. Kate, Grant, Peter J., Channon, Keith M., Beech, David J., Wheatcroft, Stephen B., Kearney, Mark T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Diabetes Association 2012
Soggetti:
Pathophysiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3425420/
https://ncbi.nlm.nih.gov/pubmed/22733797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-1494
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