Novel Role of the IGF-1 Receptor in Endothelial Function and Repair: Studies in Endothelium-Targeted IGF-1 Receptor Transgenic Mice

We recently demonstrated that reducing IGF-1 receptor (IGF-1R) numbers in the endothelium enhances nitric oxide (NO) bioavailability and endothelial cell insulin sensitivity. In the present report, we aimed to examine the effect of increasing IGF-1R on endothelial cell function and repair. To examin...

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Bibliografiske detaljer
Main Authors: Imrie, Helen, Viswambharan, Hema, Sukumar, Piruthivi, Abbas, Afroze, Cubbon, Richard M., Yuldasheva, Nadira, Gage, Matthew, Smith, Jessica, Galloway, Stacey, Skromna, Anna, Rashid, Sheik Taqweer, Futers, T. Simon, Xuan, Shouhong, Gatenby, V. Kate, Grant, Peter J., Channon, Keith M., Beech, David J., Wheatcroft, Stephen B., Kearney, Mark T.
Format: Artigo
Sprog:Inglês
Udgivet: American Diabetes Association 2012
Fag:
Pathophysiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3425420/
https://ncbi.nlm.nih.gov/pubmed/22733797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-1494
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