Nox2 NADPH Oxidase Has a Critical Role in Insulin Resistance–Related Endothelial Cell Dysfunction

Insulin resistance is characterized by excessive endothelial cell generation of potentially cytotoxic concentrations of reactive oxygen species. We examined the role of NADPH oxidase (Nox) and specifically Nox2 isoform in superoxide generation in two complementary in vivo models of human insulin res...

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Detalhes bibliográficos
Main Authors: Sukumar, Piruthivi, Viswambharan, Hema, Imrie, Helen, Cubbon, Richard M., Yuldasheva, Nadira, Gage, Matthew, Galloway, Stacey, Skromna, Anna, Kandavelu, Parkavi, Santos, Celio X., Gatenby, V. Kate, Smith, Jessica, Beech, David J., Wheatcroft, Stephen B., Channon, Keith M., Shah, Ajay M., Kearney, Mark T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2013
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3661635/
https://ncbi.nlm.nih.gov/pubmed/23349484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-1294
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