Endothelial Insulin Receptors Promote VEGF-A Signaling via ERK1/2 and Sprouting Angiogenesis

Endothelial insulin receptors (Insr) promote sprouting angiogenesis, although the underpinning cellular and molecular mechanisms are unknown. Comparing mice with whole-body insulin receptor haploinsufficiency (Insr(+/-)) against littermate controls, we found impaired limb perfusion and muscle capill...

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Bibliografiske detaljer
Udgivet i:Endocrinology
Main Authors: Walker, Andrew M N, Warmke, Nele, Mercer, Ben, Watt, Nicole T, Mughal, Romana, Smith, Jessica, Galloway, Stacey, Haywood, Natalie J, Soomro, Taha, Griffin, Kathryn J, Wheatcroft, Stephen B, Yuldasheva, Nadira Y, Beech, David J, Carmeliet, Peter, Kearney, Mark T, Cubbon, Richard M
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2021
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Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8223729/
https://ncbi.nlm.nih.gov/pubmed/34037749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/endocr/bqab104
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