DNA polymerase and mismatch repair exert distinct microsatellite instability signatures in normal and malignant human cells

Although replication repair deficiency, either by mismatch repair deficiency (MMRD) and/or loss of DNA polymerase proofreading, can cause hypermutation in cancer, microsatellite instability (MSI) is considered a hallmark of MMRD alone. By genome-wide analysis of tumors with germline and somatic defi...

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Bibliografski detalji
Izdano u:Cancer Discov
Glavni autori: Chung, Jiil, Maruvka, Yosef E., Sudhaman, Sumedha, Kelly, Jacalyn, Haradhvala, Nicholas J., Bianchi, Vanessa, Edwards, Melissa, Forster, Victoria J., Nunes, Nuno M., Galati, Melissa A., Komosa, Martin, Deshmukh, Shriya, Cabric, Vanja, Davidson, Scott, Zatzman, Matthew, Light, Nicholas, Hayes, Reid, Brunga, Ledia, Anderson, Nathaniel D., Ho, Ben, Hodel, Karl P., Siddaway, Robert, Morrissy, A. Sorana, Bowers, Daniel C., Larouche, Valérie, Bronsema, Annika, Osborn, Michael, Cole, Kristina A., Opocher, Enrico, Mason, Gary, Thomas, Gregory A., George, Ben, Ziegler, David S., Lindhorst, Scott, Vanan, Magimairajan, Yalon-Oren, Michal, Reddy, Alyssa T., Massimino, Maura, Tomboc, Patrick, Van Damme, An, Lossos, Alexander, Durno, Carol, Aronson, Melyssa, Morgenstern, Daniel A., Bouffet, Eric, Huang, Annie, Taylor, Michael D., Villani, Anita, Malkin, David, Hawkins, Cynthia E., Pursell, Zachary F., Shlien, Adam, Kunkel, Thomas A., Getz, Gad, Tabori, Uri
Format: Artigo
Jezik:Inglês
Izdano: 2020
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8223607/
https://ncbi.nlm.nih.gov/pubmed/33355208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-20-0790
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