Comprehensive Analysis of Hypermutation in Human Cancer

We present an extensive assessment of mutation burden through sequencing analysis of >81,000 tumors from pediatric and adult patients, including tumors with hypermutation caused by chemotherapy, carcinogens, or germline alterations. Hypermutation was detected in tumor types not previously associa...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Campbell, Brittany B., Light, Nicholas, Fabrizio, David, Zatzman, Matthew, Fuligni, Fabio, de Borja, Richard, Davidson, Scott, Edwards, Melissa, Elvin, Julia A., Hodel, Karl P., Zahurancik, Walter J., Suo, Zucai, Lipman, Tatiana, Wimmer, Katharina, Kratz, Christian P., Bowers, Daniel C., Laetsch, Theodore W., Dunn, Gavin P., Johanns, Tanner M., Grimmer, Matthew R., Smirnov, Ivan V., Larouche, Valérie, Samuel, David, Bronsema, Annika, Osborn, Michael, Stearns, Duncan, Raman, Pichai, Cole, Kristina A., Storm, Phillip B., Yalon, Michal, Opocher, Enrico, Mason, Gary, Thomas, Gregory A., Sabel, Magnus, George, Ben, Ziegler, David S., Lindhorst, Scott, Issai, Vanan Magimairajan, Constantini, Shlomi, Toledano, Helen, Elhasid, Ronit, Farah, Roula, Dvir, Rina, Dirks, Peter, Huang, Annie, Galati, Melissa A., Chung, Jiil, Ramaswamy, Vijay, Irwin, Meredith S., Aronson, Melyssa, Durno, Carol, Taylor, Michael D., Rechavi, Gideon, Maris, John M., Bouffet, Eric, Hawkins, Cynthia, Costello, Joseph F., Meyn, M. Stephen, Pursell, Zachary F., Malkin, David, Tabori, Uri, Shlien, Adam
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5849393/
https://ncbi.nlm.nih.gov/pubmed/29056344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.09.048
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