DNA polymerase and mismatch repair exert distinct microsatellite instability signatures in normal and malignant human cells

Although replication repair deficiency, either by mismatch repair deficiency (MMRD) and/or loss of DNA polymerase proofreading, can cause hypermutation in cancer, microsatellite instability (MSI) is considered a hallmark of MMRD alone. By genome-wide analysis of tumors with germline and somatic defi...

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Publicado no:Cancer Discov
Main Authors: Chung, Jiil, Maruvka, Yosef E., Sudhaman, Sumedha, Kelly, Jacalyn, Haradhvala, Nicholas J., Bianchi, Vanessa, Edwards, Melissa, Forster, Victoria J., Nunes, Nuno M., Galati, Melissa A., Komosa, Martin, Deshmukh, Shriya, Cabric, Vanja, Davidson, Scott, Zatzman, Matthew, Light, Nicholas, Hayes, Reid, Brunga, Ledia, Anderson, Nathaniel D., Ho, Ben, Hodel, Karl P., Siddaway, Robert, Morrissy, A. Sorana, Bowers, Daniel C., Larouche, Valérie, Bronsema, Annika, Osborn, Michael, Cole, Kristina A., Opocher, Enrico, Mason, Gary, Thomas, Gregory A., George, Ben, Ziegler, David S., Lindhorst, Scott, Vanan, Magimairajan, Yalon-Oren, Michal, Reddy, Alyssa T., Massimino, Maura, Tomboc, Patrick, Van Damme, An, Lossos, Alexander, Durno, Carol, Aronson, Melyssa, Morgenstern, Daniel A., Bouffet, Eric, Huang, Annie, Taylor, Michael D., Villani, Anita, Malkin, David, Hawkins, Cynthia E., Pursell, Zachary F., Shlien, Adam, Kunkel, Thomas A., Getz, Gad, Tabori, Uri
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8223607/
https://ncbi.nlm.nih.gov/pubmed/33355208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-20-0790
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