DNA polymerase and mismatch repair exert distinct microsatellite instability signatures in normal and malignant human cells

Although replication repair deficiency, either by mismatch repair deficiency (MMRD) and/or loss of DNA polymerase proofreading, can cause hypermutation in cancer, microsatellite instability (MSI) is considered a hallmark of MMRD alone. By genome-wide analysis of tumors with germline and somatic defi...

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Xehetasun bibliografikoak
Argitaratua izan da:Cancer Discov
Egile Nagusiak: Chung, Jiil, Maruvka, Yosef E., Sudhaman, Sumedha, Kelly, Jacalyn, Haradhvala, Nicholas J., Bianchi, Vanessa, Edwards, Melissa, Forster, Victoria J., Nunes, Nuno M., Galati, Melissa A., Komosa, Martin, Deshmukh, Shriya, Cabric, Vanja, Davidson, Scott, Zatzman, Matthew, Light, Nicholas, Hayes, Reid, Brunga, Ledia, Anderson, Nathaniel D., Ho, Ben, Hodel, Karl P., Siddaway, Robert, Morrissy, A. Sorana, Bowers, Daniel C., Larouche, Valérie, Bronsema, Annika, Osborn, Michael, Cole, Kristina A., Opocher, Enrico, Mason, Gary, Thomas, Gregory A., George, Ben, Ziegler, David S., Lindhorst, Scott, Vanan, Magimairajan, Yalon-Oren, Michal, Reddy, Alyssa T., Massimino, Maura, Tomboc, Patrick, Van Damme, An, Lossos, Alexander, Durno, Carol, Aronson, Melyssa, Morgenstern, Daniel A., Bouffet, Eric, Huang, Annie, Taylor, Michael D., Villani, Anita, Malkin, David, Hawkins, Cynthia E., Pursell, Zachary F., Shlien, Adam, Kunkel, Thomas A., Getz, Gad, Tabori, Uri
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8223607/
https://ncbi.nlm.nih.gov/pubmed/33355208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-20-0790
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