Cancers from novel Pole mutant mouse models provide insights into polymerase-mediated hypermutagenesis and immune checkpoint blockade

POLE mutations are a major cause of hypermutant cancers, yet questions remain regarding mechanisms of tumorigenesis, genotype-phenotype correlation, and therapeutic considerations. In this study, we establish mouse models harboring cancer-associated POLE mutations P286R and S459F, which cause rapid...

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Pubblicato in:Cancer Res
Autori principali: Galati, Melissa A., Hodel, Karl P., Gams, Miki S., Sudhaman, Sumedha, Bridge, Taylor, Zahurancik, Walter J., Ungerleider, Nathan A., Park, Vivian S., Ercan, Ayse B., Joksimovic, Lazar, Siddiqui, Iram, Siddaway, Robert, Edwards, Melissa, de Borja, Richard, Elshaer, Dana, Chung, Jiil, Forster, Victoria J., Nunes, Nuno M., Aronson, Melyssa, Wang, Xia, Ramdas, Jagadeesh, Seeley, Andrea, Sarosiek, Tomasz, Dunn, Gavin P., Byrd, Jonathan N., Mordechai, Oz, Durno, Carol, Martin, Alberto, Shlien, Adam, Bouffet, Eric, Suo, Zucai, Jackson, James G., Hawkins, Cynthia E., Guidos, Cynthia J., Pursell, Zachary F., Tabori, Uri
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8218238/
https://ncbi.nlm.nih.gov/pubmed/32938641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-20-0624
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