Cancers from novel Pole mutant mouse models provide insights into polymerase-mediated hypermutagenesis and immune checkpoint blockade

POLE mutations are a major cause of hypermutant cancers, yet questions remain regarding mechanisms of tumorigenesis, genotype-phenotype correlation, and therapeutic considerations. In this study, we establish mouse models harboring cancer-associated POLE mutations P286R and S459F, which cause rapid...

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Xehetasun bibliografikoak
Argitaratua izan da:Cancer Res
Egile Nagusiak: Galati, Melissa A., Hodel, Karl P., Gams, Miki S., Sudhaman, Sumedha, Bridge, Taylor, Zahurancik, Walter J., Ungerleider, Nathan A., Park, Vivian S., Ercan, Ayse B., Joksimovic, Lazar, Siddiqui, Iram, Siddaway, Robert, Edwards, Melissa, de Borja, Richard, Elshaer, Dana, Chung, Jiil, Forster, Victoria J., Nunes, Nuno M., Aronson, Melyssa, Wang, Xia, Ramdas, Jagadeesh, Seeley, Andrea, Sarosiek, Tomasz, Dunn, Gavin P., Byrd, Jonathan N., Mordechai, Oz, Durno, Carol, Martin, Alberto, Shlien, Adam, Bouffet, Eric, Suo, Zucai, Jackson, James G., Hawkins, Cynthia E., Guidos, Cynthia J., Pursell, Zachary F., Tabori, Uri
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8218238/
https://ncbi.nlm.nih.gov/pubmed/32938641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-20-0624
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