Cancers from novel Pole mutant mouse models provide insights into polymerase-mediated hypermutagenesis and immune checkpoint blockade

POLE mutations are a major cause of hypermutant cancers, yet questions remain regarding mechanisms of tumorigenesis, genotype-phenotype correlation, and therapeutic considerations. In this study, we establish mouse models harboring cancer-associated POLE mutations P286R and S459F, which cause rapid...

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Gepubliceerd in:Cancer Res
Hoofdauteurs: Galati, Melissa A., Hodel, Karl P., Gams, Miki S., Sudhaman, Sumedha, Bridge, Taylor, Zahurancik, Walter J., Ungerleider, Nathan A., Park, Vivian S., Ercan, Ayse B., Joksimovic, Lazar, Siddiqui, Iram, Siddaway, Robert, Edwards, Melissa, de Borja, Richard, Elshaer, Dana, Chung, Jiil, Forster, Victoria J., Nunes, Nuno M., Aronson, Melyssa, Wang, Xia, Ramdas, Jagadeesh, Seeley, Andrea, Sarosiek, Tomasz, Dunn, Gavin P., Byrd, Jonathan N., Mordechai, Oz, Durno, Carol, Martin, Alberto, Shlien, Adam, Bouffet, Eric, Suo, Zucai, Jackson, James G., Hawkins, Cynthia E., Guidos, Cynthia J., Pursell, Zachary F., Tabori, Uri
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8218238/
https://ncbi.nlm.nih.gov/pubmed/32938641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-20-0624
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