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Fluorinated derivatives of pyridine-2,4-dicarboxylate are potent inhibitors of human 2-oxoglutarate dependent oxygenases

2-Oxoglutarate (2OG) oxygenases have important roles in human biology and are validated medicinal chemistry targets. Improving the selectivity profile of broad-spectrum 2OG oxygenase inhibitors may help enable the identification of selective inhibitors for use in functional assignment work. We repor...

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Vydáno v:J Fluor Chem
Hlavní autoři: Brewitz, Lennart, Nakashima, Yu, Tumber, Anthony, Salah, Eidarus, Schofield, Christopher J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier Sequoia Sa 2021
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8223498/
https://ncbi.nlm.nih.gov/pubmed/34219804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jfluchem.2021.109804
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