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Inhibition of the histone demethylase JMJD2E by 3-substituted pyridine 2,4-dicarboxylates
Based on structural analysis of the human 2-oxoglutarate (2OG) dependent JMJD2 histone N(ε)-methyl lysyl demethylase family, 3-substituted pyridine 2,4-dicarboxylic acids were identified as potential inhibitors with possible selectivity over other human 2OG oxygenases. Microwave-assisted palladium-c...
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| Publicado no: | Org Biomol Chem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4733660/ https://ncbi.nlm.nih.gov/pubmed/21076780 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c0ob00592d |
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