Synthesis of Novel Pyridine‐Carboxylates as Small‐Molecule Inhibitors of Human Aspartate/Asparagine‐β‐Hydroxylase

The human 2‐oxoglutarate (2OG)‐dependent oxygenase aspartate/asparagine‐β‐hydroxylase (AspH) is a potential medicinal chemistry target for anticancer therapy. AspH is present on the cell surface of invasive cancer cells and accepts epidermal growth factor‐like domain (EGFD) substrates with a noncano...

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Bibliografiska uppgifter
I publikationen:ChemMedChem
Huvudupphovsmän: Brewitz, Lennart, Tumber, Anthony, Thalhammer, Armin, Salah, Eidarus, Christensen, Kirsten E., Schofield, Christopher J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2020
Ämnen:
Full Papers
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7383925/
https://ncbi.nlm.nih.gov/pubmed/32330361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202000147
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