Kinetic parameters of human aspartate/asparagine–β-hydroxylase suggest that it has a possible function in oxygen sensing

Human aspartate/asparagine–β-hydroxylase (AspH) is a 2-oxoglutarate (2OG)–dependent oxygenase that catalyzes the post-translational hydroxylation of Asp and Asn residues in epidermal growth factor–like domains (EGFDs). Despite its biomedical significance, studies on AspH have long been limited by a...

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Vydáno v:J Biol Chem
Hlavní autoři: Brewitz, Lennart, Tumber, Anthony, Schofield, Christopher J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2020
Témata:
Enzymology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7278358/
https://ncbi.nlm.nih.gov/pubmed/32107312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.012202
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