Large-scale tethered function assays identify factors that regulate mRNA stability and translation

The molecular functions of the majority of RNA-binding proteins (RBPs) remain unclear, highlighting a major bottleneck to a full understanding of gene expression regulation. Here, we develop a plasmid resource of 690 human RBPs that we subject to luciferase-based 3′-untranslated-region tethered func...

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Bibliographic Details
Published in:Nat Struct Mol Biol
Main Authors: Luo, En-Ching, Nathanson, Jason L., Tan, Frederick E., Schwartz, Joshua L., Schmok, Jonathan C., Shankar, Archana, Markmiller, Sebastian, Yee, Brian A., Sathe, Shashank, Pratt, Gabriel A., Scaletta, Duy B., Ha, Yuanchi, Hill, David E., Aigner, Stefan, Yeo, Gene W.
Format: Artigo
Language:Inglês
Published: 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8221285/
https://ncbi.nlm.nih.gov/pubmed/32807991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-020-0477-6
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