Large-scale tethered function assays identify factors that regulate mRNA stability and translation

The molecular functions of the majority of RNA-binding proteins (RBPs) remain unclear, highlighting a major bottleneck to a full understanding of gene expression regulation. Here, we develop a plasmid resource of 690 human RBPs that we subject to luciferase-based 3′-untranslated-region tethered func...

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Publicado en:Nat Struct Mol Biol
Main Authors: Luo, En-Ching, Nathanson, Jason L., Tan, Frederick E., Schwartz, Joshua L., Schmok, Jonathan C., Shankar, Archana, Markmiller, Sebastian, Yee, Brian A., Sathe, Shashank, Pratt, Gabriel A., Scaletta, Duy B., Ha, Yuanchi, Hill, David E., Aigner, Stefan, Yeo, Gene W.
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8221285/
https://ncbi.nlm.nih.gov/pubmed/32807991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-020-0477-6
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