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Large-scale tethered function assays identify factors that regulate mRNA stability and translation

The molecular functions of the majority of RNA-binding proteins (RBPs) remain unclear, highlighting a major bottleneck to a full understanding of gene expression regulation. Here, we develop a plasmid resource of 690 human RBPs that we subject to luciferase-based 3′-untranslated-region tethered func...

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Veröffentlicht in:	Nat Struct Mol Biol
Hauptverfasser:	Luo, En-Ching, Nathanson, Jason L., Tan, Frederick E., Schwartz, Joshua L., Schmok, Jonathan C., Shankar, Archana, Markmiller, Sebastian, Yee, Brian A., Sathe, Shashank, Pratt, Gabriel A., Scaletta, Duy B., Ha, Yuanchi, Hill, David E., Aigner, Stefan, Yeo, Gene W.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	2020
Schlagworte:	Article
Online Zugang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC8221285/ https://ncbi.nlm.nih.gov/pubmed/32807991 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-020-0477-6
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Large-scale tethered function assays identify factors that regulate mRNA stability and translation

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