A stem-loop RNA RIG-I agonist confers prophylactic and therapeutic protection against acute and chronic SARS-CoV-2 infection in mice

As SARS-CoV-2 continues to cause morbidity and mortality around the world, there is an urgent need for the development of effective medical countermeasures. Here, we assessed the antiviral capacity of a minimal RIG-I agonist, stem-loop RNA 14 (SLR14), in viral control, disease prevention, post-infec...

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Detalhes bibliográficos
Publicado no:bioRxiv
Main Authors: Mao, Tianyang, Israelow, Benjamin, Lucas, Carolina, Vogels, Chantal B. F., Fedorova, Olga, Breban, Mallery I., Menasche, Bridget L., Dong, Huiping, Linehan, Melissa, Wilen, Craig B., Landry, Marie L., Grubaugh, Nathan D., Pyle, Anna M., Iwasaki, Akiko
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8219094/
https://ncbi.nlm.nih.gov/pubmed/34159330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.06.16.448754
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