Environmentally Triggerable RIG-I Agonists Using Synthetic Polymer Overhangs

Retinoic acid-inducible gene I (RIG-I) is a cytosolic pattern recognition receptor (PRR) that potently activates antiviral innate immunity upon recognition of 5’ triphosphorylated double­stranded RNA (pppRNA). Accordingly, RNA ligands of the RIG-I pathway have recently emerged as promising antiviral...

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Bibliographic Details
Published in:Bioconjug Chem
Main Authors: Palmer, Christian R., Jacobson, Max E., Fedorova, Olga, Pyle, Anna M., Wilson, John T.
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6407425/
https://ncbi.nlm.nih.gov/pubmed/29350913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.bioconjchem.7b00697
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