Intratumoral delivery of RIG-I agonist SLR14 induces robust antitumor responses

Cytosolic nucleic acid–sensing pathways can be triggered to enhance immune response to cancer. In this study, we tested the antitumor activity of a unique RIG-I agonist, stem loop RNA (SLR) 14. In the immunogenic tumor models, we observed significant tumor growth delay and an extended survival in SL...

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Bibliografski detalji
Izdano u:J Exp Med
Glavni autori: Jiang, Xiaodong, Muthusamy, Viswanathan, Fedorova, Olga, Kong, Yong, Kim, Daniel J., Bosenberg, Marcus, Pyle, Anna Marie, Iwasaki, Akiko
Format: Artigo
Jezik:Inglês
Izdano: Rockefeller University Press 2019
Teme:
Research Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6888973/
https://ncbi.nlm.nih.gov/pubmed/31601678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20190801
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