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A minimal RNA ligand for potent RIG-I activation in living mice
We have developed highly potent synthetic activators of the vertebrate immune system that specifically target the RIG-I receptor. When introduced into mice, a family of short, triphosphorylated stem-loop RNAs (SLRs) induces a potent interferon response and the activation of specific genes essential...
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| Publicado no: | Sci Adv |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Association for the Advancement of Science
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5821489/ https://ncbi.nlm.nih.gov/pubmed/29492454 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1701854 |
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