A minimal RNA ligand for potent RIG-I activation in living mice

We have developed highly potent synthetic activators of the vertebrate immune system that specifically target the RIG-I receptor. When introduced into mice, a family of short, triphosphorylated stem-loop RNAs (SLRs) induces a potent interferon response and the activation of specific genes essential...

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Vydáno v:Sci Adv
Hlavní autoři: Linehan, Melissa M., Dickey, Thayne H., Molinari, Emanuela S., Fitzgerald, Megan E., Potapova, Olga, Iwasaki, Akiko, Pyle, Anna M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Association for the Advancement of Science 2018
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5821489/
https://ncbi.nlm.nih.gov/pubmed/29492454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1701854
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