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RNA binding activates RIG-I by releasing an autorepressed signaling domain
The retinoic acid–inducible gene I (RIG-I) innate immune receptor is an important immunotherapeutic target, but we lack approaches for monitoring the physical basis for its activation in vitro. This gap in our understanding has led to confusion about mechanisms of RIG-I activation and difficulty dis...
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| Publicado no: | Sci Adv |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Association for the Advancement of Science
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6774723/ https://ncbi.nlm.nih.gov/pubmed/31616790 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aax3641 |
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