Selective RNA targeting and regulated signaling by RIG-I is controlled by coordination of RNA and ATP binding

RIG-I is an innate immune receptor that detects and responds to infection by deadly RNA viruses such as influenza, and Hepatitis C. In the cytoplasm, RIG-I is faced with a difficult challenge: it must sensitively detect viral RNA while ignoring the abundance of host RNA. It has been suggested that R...

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Foilsithe in:Nucleic Acids Res
Main Authors: Fitzgerald, Megan E., Rawling, David C., Potapova, Olga, Ren, Xiaoming, Kohlway, Andrew, Pyle, Anna Marie
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2017
Ábhair:
RNA
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5388420/
https://ncbi.nlm.nih.gov/pubmed/28180316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw816
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