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Defining the functional determinants for RNA surveillance by RIG-I
Retinoic acid-inducible gene-I (RIG-I) is an intracellular RNA sensor that activates the innate immune machinery in response to infection by RNA viruses. Here, we report the crystal structure of distinct conformations of a RIG-I:dsRNA complex, which shows that HEL2i-mediated scanning allows RIG-I to...
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| Main Authors: | , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
European Molecular Biology Organization
2013
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3790051/ https://ncbi.nlm.nih.gov/pubmed/23897087 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2013.108 |
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