Defining the functional determinants for RNA surveillance by RIG-I

Retinoic acid-inducible gene-I (RIG-I) is an intracellular RNA sensor that activates the innate immune machinery in response to infection by RNA viruses. Here, we report the crystal structure of distinct conformations of a RIG-I:dsRNA complex, which shows that HEL2i-mediated scanning allows RIG-I to...

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Detalles Bibliográficos
Main Authors: Kohlway, Andrew, Luo, Dahai, Rawling, David C, Ding, Steve C, Pyle, Anna Marie
Formato: Artigo
Idioma:Inglês
Publicado: European Molecular Biology Organization 2013
Assuntos:
Scientific Reports
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3790051/
https://ncbi.nlm.nih.gov/pubmed/23897087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2013.108
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