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Visualizing the determinants of viral RNA recognition by innate immune sensor RIG-I
Retinoic acid inducible gene-I (RIG-I) is a key intracellular immune receptor for pathogenic RNAs, particularly from RNA viruses. Here we report the crystal structure of human RIG-I bound to a 5′tri-phosphorylated RNA hairpin and ADP nucleotide at 2.8Å resolution. The RNA ligand contains all structu...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3515076/ https://ncbi.nlm.nih.gov/pubmed/23022350 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2012.08.029 |
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