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Establishing the role of ATP for the function of the RIG-I innate immune sensor

Retinoic acid-inducible gene I (RIG-I) initiates a rapid innate immune response upon detection and binding to viral ribonucleic acid (RNA). This signal activation occurs only when pathogenic RNA is identified, despite the ability of RIG-I to bind endogenous RNA while surveying the cytoplasm. Here we...

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Bibliographic Details
Published in:eLife
Main Authors: Rawling, David C, Fitzgerald, Megan E, Pyle, Anna Marie
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2015
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622095/
https://ncbi.nlm.nih.gov/pubmed/26371557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.09391
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