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The RIG-I ATPase core has evolved a functional requirement for allosteric stabilization by the Pincer domain
Retinoic acid-inducible gene I (RIG-I) is a pattern recognition receptor expressed in metazoan cells that is responsible for eliciting the production of type I interferons and pro-inflammatory cytokines upon detection of intracellular, non-self RNA. Structural studies of RIG-I have identified a nove...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
2014
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4191399/ https://ncbi.nlm.nih.gov/pubmed/25217590 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku817 |
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