Structural Insights into the Mechanisms of Action of Functionally Distinct Classes of Chikungunya Virus Nonstructural Protein 1 Inhibitors

Chikungunya virus (CHIKV) nonstructural protein 1 (nsP1) harbors the methyltransferase (MTase) and guanylyltransferase (GTase) activities needed for viral RNA capping and represents a promising antiviral drug target. We compared the antiviral efficacies of nsP1 inhibitors belonging to the MADTP, CHV...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Kovacikova, Kristina, Gorostiola González, Marina, Jones, Rhian, Reguera, Juan, Gigante, Alba, Pérez-Pérez, María-Jesús, Pürstinger, Gerhard, Moesslacher, Julia, Langer, Thierry, Jeong, Lak Shin, Delang, Leen, Neyts, Johan, Snijder, Eric J., van Westen, Gerard J. P., van Hemert, Martijn J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2021
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8218635/
https://ncbi.nlm.nih.gov/pubmed/33875421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02566-20
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