6′-β-Fluoro-Homoaristeromycin and 6′-Fluoro-Homoneplanocin A Are Potent Inhibitors of Chikungunya Virus Replication through Their Direct Effect on Viral Nonstructural Protein 1

Alphaviruses are arthropod-borne, positive-stranded RNA viruses capable of causing severe disease with high morbidity. Chikungunya virus (CHIKV) is an alphavirus that causes a febrile illness which can progress into chronic arthralgia. The current lack of vaccines and specific treatment for CHIKV in...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Kovacikova, Kristina, Morren, Bas M., Tas, Ali, Albulescu, Irina C., van Rijswijk, Robin, Jarhad, Dnyandev B., Shin, Young Sup, Jang, Min Hwan, Kim, Gyudong, Lee, Hyuk Woo, Jeong, Lak Shin, Snijder, Eric J., van Hemert, Martijn J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2020
Fag:
Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7179274/
https://ncbi.nlm.nih.gov/pubmed/31964798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02532-19
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