Novel Class of Chikungunya Virus Small Molecule Inhibitors That Targets the Viral Capping Machinery

Despite the worldwide reemergence of the chikungunya virus (CHIKV) and the high morbidity associated with CHIKV infections, there is no approved vaccine or antiviral treatment available. Here, we aimed to identify the target of a novel class of CHIKV inhibitors, i.e., the CHVB series. CHVB compounds...

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發表在:Antimicrob Agents Chemother
Main Authors: Abdelnabi, Rana, Kovacikova, Kristina, Moesslacher, Julia, Donckers, Kim, Battisti, Verena, Leyssen, Pieter, Langer, Thierry, Puerstinger, Gerhard, Quérat, Gilles, Li, Changqing, Decroly, Etienne, Tas, Ali, Marchand, Arnaud, Chaltin, Patrick, Coutard, Bruno, van Hemert, Martijn, Neyts, Johan, Delang, Leen
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2020
主題:
Antiviral Agents
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7317993/
https://ncbi.nlm.nih.gov/pubmed/32340991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00649-20
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