Novel Class of Chikungunya Virus Small Molecule Inhibitors That Targets the Viral Capping Machinery

Despite the worldwide reemergence of the chikungunya virus (CHIKV) and the high morbidity associated with CHIKV infections, there is no approved vaccine or antiviral treatment available. Here, we aimed to identify the target of a novel class of CHIKV inhibitors, i.e., the CHVB series. CHVB compounds...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Abdelnabi, Rana, Kovacikova, Kristina, Moesslacher, Julia, Donckers, Kim, Battisti, Verena, Leyssen, Pieter, Langer, Thierry, Puerstinger, Gerhard, Quérat, Gilles, Li, Changqing, Decroly, Etienne, Tas, Ali, Marchand, Arnaud, Chaltin, Patrick, Coutard, Bruno, van Hemert, Martijn, Neyts, Johan, Delang, Leen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7317993/
https://ncbi.nlm.nih.gov/pubmed/32340991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00649-20
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