Structural insights into the human D1 and D2 dopamine receptor signaling complexes

The D1- and D2-dopamine receptors (D1R and D2R), which signal through G(s) and G(i), respectively, represent the principal stimulatory and inhibitory dopamine receptors in the central nervous system. D1R and D2R also represent the main therapeutic targets for Parkinson’s disease, schizophrenia, and...

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Vydáno v:Cell
Hlavní autoři: Zhuang, Youwen, Xu, Peiyu, Mao, Chunyou, Wang, Lei, Krumm, Brian, Zhou, X. Edward, Huang, Sijie, Liu, Heng, Cheng, Xi, Huang, Xi-Ping, Shen, Dan-Dan, Xu, Tinghai, Liu, Yong-Feng, Wang, Yue, Guo, Jia, Jiang, Yi, Jiang, Hualiang, Melcher, Karsten, Roth, Bryan L., Zhang, Yan, Zhang, Cheng, Xu, H. Eric
Médium: Artigo
Jazyk:Inglês
Vydáno: 2021
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8215686/
https://ncbi.nlm.nih.gov/pubmed/33571431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2021.01.027
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