Modulating Polymer-siRNA Binding Does Not Promote Polyplex-Mediated Silencing

The development of delivery vehicles for small interfering RNAs (siRNAs) remains a bottleneck to widespread clinical use. Cationic polymers represent an important class of potential delivery vehicles. In this study, we used alkyne-azide click chemistry to synthesize a variety of cationic poly(propar...

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Detalhes bibliográficos
Publicado no:Nucleic Acid Ther
Main Authors: Splichal, R. Chauncey, Gredell, Joseph A., Vogel, Erin B., Malefyt, Amanda, Comiskey, Georgina, Smith, Milton R., Chan, Christina, Walton, S. Patrick
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc., publishers 2021
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Original Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8215420/
https://ncbi.nlm.nih.gov/pubmed/32749923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/nat.2020.0857
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