Clonal hematopoiesis associated with epigenetic aging and clinical outcomes

Clonal hematopoiesis of indeterminate potential (CHIP) is a common precursor state for blood cancers that most frequently occurs due to mutations in the DNA‐methylation modifying enzymes DNMT3A or TET2. We used DNA‐methylation array and whole‐genome sequencing data from four cohorts together compris...

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Publicat a:Aging Cell
Autors principals: Nachun, Daniel, Lu, Ake T., Bick, Alexander G., Natarajan, Pradeep, Weinstock, Joshua, Szeto, Mindy D., Kathiresan, Sekar, Abecasis, Goncalo, Taylor, Kent D., Guo, Xiuqing, Tracy, Russ, Durda, Peter, Liu, Yongmei, Johnson, Craig, Rich, Stephen S., Van Den Berg, David, Laurie, Cecilia, Blackwell, Tom, Papanicolaou, George J., Correa, Adolfo, Raffield, Laura M., Johnson, Andrew D., Murabito, Joanne, Manson, JoAnn E., Desai, Pinkal, Kooperberg, Charles, Assimes, Themistocles L., Levy, Daniel, Rotter, Jerome I., Reiner, Alex P., Whitsel, Eric A., Wilson, James G., Horvath, Steve, Jaiswal, Siddhartha
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2021
Matèries:
Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8208788/
https://ncbi.nlm.nih.gov/pubmed/34050697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13366
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