Genetic IL-6 signaling deficiency attenuates cardiovascular risk in clonal hematopoiesis

BACKGROUND: Clonal hematopoiesis of indeterminate potential (CHIP) refers to clonal expansion of hematopoietic stem cells due to acquired leukemic mutations in genes such as DNMT3A or TET2. In humans, CHIP associates with prevalent myocardial infarction. In mice, CHIP accelerates atherosclerosis and...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Circulation
Hlavní autoři: Bick, Alexander G., Pirruccello, James P., Griffin, Gabriel K., Gupta, Namrata, Gabriel, Stacey, Saleheen, Danish, Libby, Peter, Kathiresan, Sekar, Natarajan, Pradeep
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7008855/
https://ncbi.nlm.nih.gov/pubmed/31707836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.119.044362
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky