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Genetic IL-6 signaling deficiency attenuates cardiovascular risk in clonal hematopoiesis

BACKGROUND: Clonal hematopoiesis of indeterminate potential (CHIP) refers to clonal expansion of hematopoietic stem cells due to acquired leukemic mutations in genes such as DNMT3A or TET2. In humans, CHIP associates with prevalent myocardial infarction. In mice, CHIP accelerates atherosclerosis and...

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Detalhes bibliográficos
Publicado no:Circulation
Main Authors: Bick, Alexander G., Pirruccello, James P., Griffin, Gabriel K., Gupta, Namrata, Gabriel, Stacey, Saleheen, Danish, Libby, Peter, Kathiresan, Sekar, Natarajan, Pradeep
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7008855/
https://ncbi.nlm.nih.gov/pubmed/31707836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.119.044362
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